nervous system (CNS), caused by CTG repeat expansion on the chromosome 19q. In some patients CNS white matter abnormalities are very extensive, with clinical symptoms including mental changes, hypersomnia, stroke-like episodes and seizures. Participants, Materials/Methods: We report two unrelated patients with DM1. Results: One patient, 50-year-old woman, at the time of clinical examination manifested mild temporal and bulbar muscle weakness, slight flexor neck, distal limb weakness, mild intermittent myotonia. She have bilateral cataract, sterility, without cardiac pathology. Elevated CK (274 U/l). Generalized myotonia and myopathic changes in EMG. Skeletal muscle biopsy compatible with myotonic dystrophy. Cerebrospinal fluid (CSF) was normal without immunological activity. The other patient was 37-year-old man. Clinical examination revealed severe temporal, ocular and bulbar muscle weakness, anterior neck and distal limb muscle weakness, mild myotonia as well as the frontal balding, sterility, bilateral cataract, severe myocardiopathy, elevated CK (280 U/l), generalized myotonia and myopathic changes in EMG, muscle biopsy compatible with DM1. CSF was normal. MRI of the brain in two patients: bilateral, multifocal, subcortical white matter changes, paraventricular and in brain steam, hyperintense on T2-weighted and proton density-weighted images. MRI of cervical spinal cord and MRI cerebral angiography were normal. Conclusions: We found definite MRI abnormalities in 2 patients with DM1. The morphology underlying this leucoencephalopathy is unknown. Examination of the CSF gave no evidence of an inflammatory process, excluding multiple sclerosis. These changes are probably with vascular etiology, and they are part from wide spectrum of musltisystemic disorders in DM1. Multiple sclerosis (MS) is a disease of the central nervous system (CNS), beginning most often in late adolescence and early adult life and expressing itself by reccurrent attacks of spinal cord, brainstem, cerebellar, optic nerve and cerebral dysfunction, the result of foci of destrucion of myelinated fibers. In this retrospective study we evaluated 280 patients who have been hospitalised at Department of neurology in last 3 years. According to the results of our study one hundred and four patients (60%) had either an acute or chronic pain syndrome at some time during their disease. Sixth patients (2.1%) with acute pain syndromes had episodes of paroxismal pain attacks in distribution of trigeminal nerve. Chronic pain syndromes, present for a mean duration of 4.2 years occurred in 154 patients (55%) and included headache (38%), cervical and lumbosacral syndrome (58%) and painful leg spasms in 4% of patients.