Hydroxamic acids
are present in a several pharmaceuticals and agrochemicals.
Synthetic strategies providing access to hydroxamic acid derivatives
remain limited, typically requiring the use of nucleophilic hydroxylamine
reagents. Herein, a synthesis of hydroxamates from unactivated carboxylic
acids is reported making use of rare blocked (masked) O-substituted isocyanates. The applicability of this transformation
was highlighted by targeting the synthesis of vorinostat and belinostat
derivatives.
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