Aminophylline increases the contractile force of fatiguing muscles. The effects of aminophylline upon maximal exercise performance are not defined. 6 healthy men performed incremental bicycle ergometry before and after receiving intravenous aminophylline (6 mg/kg). Maximal oxygen uptake, maximum work rate, and maximum minute ventilation were unchanged following aminophylline. Heart rate measured at rest and at 50-watt increments of work rate was significantly increased following aminophylline (p < 0.03). The heart rate response to incremental exercise (Δ HR/ΔVO2) was unchanged by aminophylline. We conclude that aminophylline does not increase maximal exercise performance of healthy men.
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