An important goal of educational research is to find out which teaching practices are effective in promoting students' learning. In order to assess these practices, adequate observation instruments are needed. Existing observation schemes for language teaching are not suitable to gauge which teaching strategies scaffold EFL reading comprehension in particular and language learning in general. Therefore, we developed a new instrument: the English Reading Comprehension Observation Protocol. The focus of the instrument is on the role of the EFL teacher who helps students to move from learning to read to reading to learn in English. We conducted a generalizability study in order to establish the instrument's reliability. Twenty lessons taught by five experienced teachers were recorded and observed by five experienced teacher educators. The results of the generalizability study, in which we disentangled sources of variance, show that a large proportion of the variance can be attributed to differences between the teachers. This shows that the instrument has a high reliability and can help teachers identify their strengths and room for development. The instrument takes the form of a checklist and is easy to use for professional development purposes.
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Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype. Despite the proven efficacy of combined immunochemotherapy (R-CHOP) in the majority of patients, ~40% of DLBCL patients do not respond or will relapse and consequently have a very poor prognosis. The development of targeted therapies has not improved patient survival, underscoring the need for new treatment approaches. Using an unbiased genome-wide CD20 guilt-by-association approach in more than 1800 DLBCL patients, we previously identified the estrogen receptor beta (ERβ) as a new target in DLBCL. Here, we demonstrate that ERβ is expressed at significantly higher levels in DLBCL compared to normal B cells, and ERβ plays a role in the protection against apoptosis in DLBCL. Targeting of the ERβ with the selective estrogen receptor modulator tamoxifen reduces cell viability in all tested DLBCL cell lines. Tamoxifen-induced cell death was significantly decreased in an ERβ knock-out cell line. The activity of tamoxifen was confirmed in a xenograft human lymphoma model, as tumor growth decreased, and survival significantly improved. Finally, tamoxifen-treated breast cancer (BC) patients showed a significantly reduced risk of 38% for DLBCL compared to BC patients who did not receive tamoxifen. Our findings provide a rationale to investigate tamoxifen, a hormonal drug with a good safety profile, in DLBCL patients.
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