Thirty-six patients, aged 12-75 years, with dry, central tympanic membrane perforations and a negative Valsalva manouevre and/or a negative aspiration/deflation test, were included in a randomized, double-blind, placebo-controlled trial on the effect of a decongestant agent (xylometazoline chloride 0.1%) and placebo (saline 0.9%) applied directly to the pharyngeal opening of the Eustachian tube. Judged by the Valsalva manouevre, tubal patency was significantly improved after application of the active drug (P less than 0.003). In contrast, no effect was demonstrated by the aspiration test (P = 0.80) or the deflation test (P = 0.51). It is concluded that a topical decongestant improves Eustachian tube function but only at unphysiologically high pressures.
The investigation includes 43 children (82 ears) with acute otitis media who were treated with paracentesis and antibiotics. The middle ear pressure was measured 7 days, 14 days, 1 month, and 2 months after the otitis. A follow-up examination was performed 4–12 months after the otitis. The normalization process was extremely slow: 3 months after the otitis only 37% of the ears had a pressure between 0 and -50 mm H2O, and 24% had flat curves and chronic secretory otitis. 3–12 months after, 49% of the ears had a normal pressure. A discussion on whether the middle ear ventilation had been reduced before the present otitis, or whether the slow normalization process is due to the changes in the mucous membrane is presented. The first assumption seems to be more probable. The significance of poor ventilation in the occurrence of recurrency is emphasized. Tympanometry is recommended 1–3 months after otitis, especially in recurrent otitis media. The literature on acute suppurative otitis media is very extensive and reveals widely differing opinions on treatment, causes of therapeutic failure, and recurrency. Although commonly agreed that it is a bacterial infection, the distribution of the pathogenic bacteria and the frequency of negative bacterial findings in the secretion vary greatly in the different materials (Lundgren, 1972). Today, the treatment follows several different principles: (1)no primary antibiotic treatment or paracentesis (Meistrup-Larsen et al., 1977); (2) primary antibiotic treatment without paracentesis (Lorentzen and Haugsten, 1977); (3) paracentesis and antibiotic timing treatment on signs of complications (Diamant and Diamant, 1974); (4) primary paracentesis without antibiotics; (5) paracentesis with antibiotics (Lundgren, 1972). The therapeutic effect is considered as being successful when the patient is free of symptoms, the eardrum appears normal and mobile in Siegle’s pneumotic otoscope, and hearing is normal. However, the time of evaluation may vary according to the initial appearance of the disease. The aim of this work has been to investigate prospectively ventilation of the middle ear based on tympanometry performed at various stages after acute otitis. Although it appears valuable when judging the therapeutic effect to include ventilation of the middle ear, apparently only Meistrup-Larsen et al. (1978) have done so when investigating the effect of norephedrine on acute otitis. They found that 14 days after the onset of the disease, 8 out of 100 children did not have normal tympanograms and drums.
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