The hybridization of oligothymine templates with oligomeric adenine and naphthalene diaminotriazine guests has been studied by UV-vis and circular dichroism (CD) spectroscopy. First, the length of the oligothymine template and the oligoadenine guest has been systematically varied. The studies reveal that increasing the length of multivalent guests results in a stabilization of the templated assemblies. Hybridization studies also show that guest-guest interactions between the multivalent guests additionally enhance the stability. Based on these results, a bivalent naphthalene diaminotriazine guest has been synthesized, showing a higher stability than the monovalent naphthalene diaminotriazine guest; the host-guest interaction energy is higher while the guest-guest interaction remains the same.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.