Aim. The aim of this study was to assess ocular and mucocutaneous sequelae among SJS/TEN survivors and identify risk factors of ocular sequelae. Patients and Method. Late complications among SJS/TEN survivors were assessed using 2 methods: a retrospective assessment of medical records only or a retrospective assessment of medical records and physical examination of survivors who were contacted by phone. Results. Between January 1995 and December 2017, 177 cases of SJS/TEN (138 cases of SJS, 29 cases of TEN, and 10 cases SJS/TEN overlap) were admitted into two university hospitals of Lomé (Togo). There were 113 women and 64 men, with an average age of 31.7±13.0 years (range: 5 to 80 years). The most used drugs were antibacterial sulfonamides (35.6%) and nevirapine (24.3%). HIV serology was positive in 68 (59.1%) of the 115 patients tested. Sixty-four (52,5%) of the 122 patients, who had been examined by an ophthalmologist during the acute stage, had acute ocular involvement, which was mild in 27.9% of patients, moderate in 13.1%, and severe in 11.5%. We recorded 17 deaths (i.e., three cases of SJS, 12 of TEN, and two of SJS/TEN overlap), including 11 cases of HIV infected patients. Of the 160 SJS/TEN survivors, only 71 patients were assessed 6 months after hospital discharge. Among them, forty-three (60.6%) patients had sequelae. Concerning mucocutaneous sequelae, the main lesions were diffuse dyschromic macules (38.0% of patients) and ocular sequelae were dominated by decreased visual acuity (14.1% of patients). In multivariate analysis, exposure to sulfadoxine (odds adjusted ratio = 5.95; 95%CI= [1.36-31.35]) and moderate (adjusted odds ratio = 5.85; 95%CI = [1.23-31.81]) or severe (adjusted odds ratio = 48.30; 95%CI = [6.25-1063.66]) ocular involvement at acute stage were associated with ocular sequelae. Conclusion. Ocular and mucocutaneous sequelae are common in SJS/TEN survivors. Exposure to sulfadoxine and severity of acute ocular involvement are risk factors of ocular sequelae.

Background: The elderly cancers are worldwide a major public health issue. Their exact incidence is unknown in Togo. The purpose of this study was to describe epidemiological and histological data of cancers in the elderly in Togo. Materials and Methods: This was a cross-sectional and descriptive study of cases of elderly cancers diagnosed at the laboratory of pathology of the university teaching hospital of Lomé from 1995 to 2014 (20 years). Cases of examination on samples of the elderly (biopsy, excision, surgical specimens) were collected from the data records of that laboratory. Results: Overall, 792/5200 cases of elderly cancer were collected representing 15.2% of all cancers diagnosed in the laboratory. The annual incidence was 39.6 cases. Patient age ranged from 65 to 103 years old, with a mean of 68.5 ± 4 years old. The sex ratio (M/F) was 1.3. At pathological level, the study material included pieces (n=290 cases; 36.6%) and biopsies (n=502 cases; 63.4%). Cancers located preferably in prostate in men (38%), and in women the most frequent locations were cervix (16.2%) and breast (15.8%). We noticed four histological groups: carcinomas (n = 706 cases; 89.1%), sarcomas (n = 43 cases; 5.5%), lymphoma (n = 34 cases; 4.3%) and melanoma (n = 9 cases; 1.1%). Carcinomas were dominated by adenocarcinomas (50.1%) and squamous cell carcinomas (33.8%); Kaposi's sarcoma (32.6%) was the most common histological type in sarcomas. Conclusion: Our results showed that the elderly cancers were frequent in Togo, locating mostly in uterus cervix and breast in female, and prostate in men. This study could help to advocate the establishment of a cancer registry in Togo.

Background: Cancer is a subject of continuing concern, more common in adults than in children, but often with a poor outcome in the latter. Our study set itself the objective to describe the epidemiological and histological aspects of solid cancers in children in Togo. Materials and Methods: This descriptive, cross-sectional study focused on cases of solid cancers in children diagnosed from 2010 to 2014 (5 years) at the pathology laboratory of the Tokoin teaching hospital. Data were collected from the records of that laboratory. Results: We collected 66 cases of childhood cancer representing 5% of all solid cancers. The annual incidence was 13.2 cases. The sex ratio (M/F) was 1.4; mean age was of 7.2±1.6 years. The age group most affected was that of 5-9 years (40.9%). Four histological groups of solid childhood cancers were listed: lymphoma (n=34 cases; 51.5%), embryonic cancer (n=17 cases; 25.8%), sarcomas (n=13 cases; 19.7%) and carcinoma (n=2 cases; 3%). The most common histological types were Burkitt lymphoma (36.4%), nephroblastoma (10.6%) and retinoblastoma (10.6%). Conclusions: This study shows that solid cancers in children are relatively frequent in Togo with a male predominance. They are still largely dominated by Burkitt lymphoma, followed by retinoblastoma and nephroblastoma.

Introductionle décollement de rétine pose un problème de prise en charge dans les pays en développement par manque de plateau technique. Sa prévention passe par la connaissance et l'éviction de ses facteurs de risque. Le but de l'étude était d'identifier les facteurs de risque du décollement de rétine chez le Togolais. Méthode: il s'est agi d'une étude rétrospective et descriptive, réalisée dans le service d'ophtalmologie du Chu-Campus et dans un cabinet privé d'ophtalmologie de Lomé du 2 Janvier 2011 à 31 Décembre 2015. Ont été inclus dans l'étude les dossiers des patients portant le diagnostic de décollement de rétine. Le diagnostic de décollement de rétine avait été retenu devant: la présence d'un décollement de rétine à l'examen du fond d'œil ou à l'échographie oculaire.Méthodesil s'est agi d'une étude rétrospective et descriptive, réalisée dans le service d'ophtalmologie du Chu-Campus et dans un cabinet privé d'ophtalmologie de Lomé du 2 Janvier 2011 à 31 Décembre 2015. Ont été inclus dans l'étude les dossiers des patients portant le diagnostic de décollement de rétine. Le diagnostic de décollement de rétine avait été retenu devant: la présence d'un décollement de rétine à l'examen du fond d'œil ou à l'échographie oculaire.Résultatsau total, 116 yeux de 100 patients avaient un décollement de rétine dont 40 à l'OD, 44 à l'OG et 16 bilatéraux (32yeux). L'âge moyen des patients était de 46,65 ± 16,46 ans [07 ans ; 87 ans], une prédominance masculine et avec un sex-ratio = 0,32 (F/H). Les diabétiques représentaient 17% et les patients drépanocytaires 16%. Les patients myopes représentaient 5%, les yeux pseudophaques représentaient 17,2% et les yeux aphaques 3,4%. Quatre déchirures rétiniennes (14,28 % des DR rhegmatogènes) étaient retrouvées dont 2 déchirures en supéro-temporal, une déchirure en inféro-nasal et une déchirure en inféro-temporal. Le décollement était total pour 35 yeux (52,2%) et partiel pour 24 yeux (35,8%). Vingt yeux présentaient des proliférations vitréo-rétiniennes, 5 yeux avaient un vitré hémorragique et 6 yeux une hyalite. Le diabète et la drépanocytose étaient les facteurs de risque du DR tractionnel (p=0,006 et p=0,0003), et la chirurgie de cataracte le facteur de risque du DR rhegmatogène (p=0,0097).Conclusionle diabète, la drépanocytose et la chirurgie oculaire étaient les facteurs de risque les plus importants du DR. Une meilleure prise en charge de ces pathologies et une maîtrise de la chirurgie de la cataracte par l'ophtalmologiste préviendraient le décollement de rétine.