Alzheimer's disease (AD) is a multifactorial syndrome with several target proteins contributing to its etiology. To confront AD, an innovative strategy is to design single chemical entities able to simultaneously modulate more than one target. Here, we present compounds that inhibit acetylcholinesterase and NMDA receptor activity. Furthermore, these compounds inhibit AChE-induced Abeta aggregation and display antioxidant properties, emerging as lead candidates for treating AD.

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The studies presented in this article are based on the variation of some constructive parameters on various types of materials for a prehension system jaws. The pneumatic actuation prehension system is part of the structure of a manipulator integrated within a teaching platform for installation. In the tests, the varied parameters were the following: the type of plastic material, the way of printing on the 3D printer bed, the degree of fill (the density) and the geometric shape. The experimental tests have resulted in an optimal version of the prehension system jaws.

The paper shows the importance of designing an ABS (Acrylonitrile-Butadiene-Styrene) plastic part which will be produced using FDM (Fused Deposition Modeling) technology; it is obtained a product with the same characteristics provided by the operating guide book. Thus, this solution combines both the capacity of the designer as well as the applied technology and can produce similar or improved plastic components, at the same time maintaining the functional characteristics of the work piece. This paper is a plea for the application of 3D printing using FDM technology for manufacturing components (spare parts) out of production, because the technological systems users no longer have other solutions available for replacing outworn plastic parts. 3D printing using FDM technology is a fast option for replacing outworn components, the modeling, simulation and printing time being shorter than the purchase time of a new subassembly or assembly that has been remanufactured and modernized.