Infectious salmon anaemia virus (ISAV) belongs to the FamilyOrthomyxoviridae and is the sole member of the Genus Isavirus (International Committee on Taxonomy of Viruses, 2020). The virus genome is comprised of eight single-stranded RNA segments coding for at least 10 proteins. Among the proteins encoded, there are two surface glycoproteins: haemagglutinin-esterase (HE), responsible for receptor-binding and receptor-destruction, and a fusion (F) protein (Aspehaug et al., 2005;Clouthier et al., 2002;Falk et al., 1997;Rimstad et al., 2011). The HE protein is encoded by gene segment 6, in which a highly polymorphic region (HPR) has been identified (Falk et al., 2004;Mjaaland et al., 2002). This segment has been used for genotyping purposes and identification of different
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