Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate mammalian tissue age with high accuracy (r > 0.96). Age deviations correlate with human mortality risk, mouse somatotropic axis mutations and caloric restriction. We identified specific cytosines with methylation levels that change with age across numerous species. These sites, highly enriched in polycomb repressive complex 2-binding locations, are near genes implicated in mammalian development, cancer, obesity and longevity. Our findings offer new evidence suggesting that aging is evolutionarily conserved and intertwined with developmental processes across all mammals.
Flipping or inverting a course is a relatively new approach to structuring a course. Using this method, the lectures traditionally delivered during regularly scheduled class time are converted to a media for delivery online, often in the form of videos. Learners are expected to view the online lectures prior to class. Then in turn, in-class time is used for a variety of application-type activities. This study documents participants' perceptions of flipping an agricultural education teaching methods course. Based on data from a focus group, we concluded that the participants thought the flipped classroom approach aided their learning of the teaching methods and the teaching and learning principles presented in the course. However, the participants offered numerous suggestions for improving the flipped classroom experience.
Engaging students emotionally is the key to strengthening their dispositions toward critical thinking. Elder (1997) contends that it is critical thinking which leads us to a rational and reasonable emotional life. The link between thinking and emotions is essential in leadership education. With this in mind, the researchers sought to examine the relationship between the skill sets of emotional intelligence (Developing Your Emotional Intelligence) and the dispositions of critical thinking (EMI). The researchers identified positive relationships ranging in magnitude from low to substantial. The overall skills associated with emotional intelligence showed positive moderate relationships with cognitive maturity, engagement, and innovativeness. In considering EMI critical thinking disposition scores and emotional intelligence, the relationship was substantially positive. The conclusions and recommendations encourage educators to take advantage of this relationship by providing students with experiences which elicit their emotional intelligence. In so doing there is opportunity to strengthen their disposition toward critical thinking.
Volunteer administration leadership is an important component of any successful 4-H program. Proficiency in competencies associated with volunteer administration can prove to be one's greatest asset in his/her ability to successfully develop the leadership of youth. With that, leadership style is also an important consideration because it provides a means for working with individuals and reaching programmatic goals. The purpose of this research was to determine factors which contribute to volunteer administration leadership proficiency of 4-H county faculty in the southern region. In order to do this, demographics and correlations among identified independent variables were analyzed. The primary intent was to develop a prediction equation for perceived proficiency in VAL competence. Although seven variables correlated with perceived proficiency in VAL competence, organizational culture (importance) and age were responsible for 43% of the variation in the model. These factors can guide efforts related to volunteer programming, including professional development opportunities for 4-H county faculty in the southern region. A focused curriculum addressing organizational culture and a mentoring program for faculty has the potential to increase VAL proficiency.
Training undergraduate agricultural students to be strong, positive leaders will have a large impact on the industries they work within and therefore should be of utmost importance to agricultural educators. Transformational leaders (TL)
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.