Objective To assess the feasibility of recruiting and retaining cancer survivors with lower limb lymphedema into an exercise intervention study. To develop preliminary estimates regarding the safety and efficacy of this intervention. We hypothesized that progressive weight training would not exacerbate leg swelling and that the intervention would improve functional mobility and quality of life. Design Before-after pilot study of 5 months duration. Setting University of Pennsylvania Participants Cancer survivors with a known diagnosis of lower limb lymphedema (N=10) were directly referred by University of Pennsylvania clinicians. All 10 participants completed the study. Intervention Twice weekly slowly progressive weight-lifting, supervised for 2 months, unsupervised for 3 months. Main Outcome Measures The primary outcome was interlimb volume differences as measured by optoelectronic perometry. Additional outcome measures included safety (adverse events), muscle strength, objective physical function, and quality of life. Results Interlimb volume differences were 44.4 and 45.3% at baseline and 5 months, respectively (pre-post comparison, p = 0.70). There were 2 unexpected incident cases of cellulitus within the first two months. Both resolved with oral antibiotics and complete decongestive therapy by 5 months. Bench and leg press strength increased by 47% and 27% over 5 months (p = 0.001 and p = 0.07, respectively). Distance walked in 6 minutes increased by 7% in 5 months (p = 0.01). No improvement was noted in self-reported quality of life. Conclusions Recruitment of patients with lower limb lymphedema into an exercise program is feasible. Despite some indications that the intervention may be safe (e.g., a lack of clinically significant interlimb volume increases over 5 months), the unexpected finding of two cellulitic infections among the 10 participants suggests additional study is required before concluding lower extremity lymphedema patients can safely perform weight-lifting.
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