Reaction rate constants and deuterium kinetic isotope effects for the reactions of BrO(-) with RCl (R = methyl, ethyl, isopropyl, and tert-butyl) were measured using a tandem flowing afterglow-selected ion flow tube instrument. These results provide qualitative insight into the competition between two classical organic mechanisms, nucleophilic substitution (S(N)2) and base-induced elimination (E2). As the extent of substitution in the neutral reactants increases, the kinetic isotope effects become increasingly more normal, consistent with the gradual onset of the E2 channel. These results are in excellent agreement with previously reported trends for the analogous reactions of ClO(-) with RCl. [Villano et al. J. Am. Chem. Soc. 2006, 128, 728.] However, the reactions of BrO(-) and ClO(-) with methyl chloride, ethyl chloride, and isopropyl chloride were found to occur by an additional reaction pathway, which has not previously been reported. This reaction likely proceeds initially through a traditional S(N)2 transition state, followed by an elimination step in the S(N)2 product ion-dipole complex. Furthermore, the controversial alpha-nucleophilic character of these two anions and of the HO(2)(-) anion is examined. No enhanced reactivity is displayed. These results suggest that the alpha-effect is not due to an intrinsic property of the anion but instead due to a solvent effect.

Direct comparisons of the reactivity and mechanistic pathways for anionic systems in the gas phase and in solution are presented. Rate constants and kinetic isotope effects for the reactions of methyl, ethyl, isopropyl, and tert-butyl iodide with cyanide ion in the gas phase, as well as for the reactions of methyl and ethyl iodide with cyanide ion in several solvents, are reported. In addition to measuring the perdeutero kinetic isotope effect (KIE) for each reaction, the secondary alpha- and beta-deuterium KIEs were determined for the ethyl iodide reaction. Comparisons of experimental results with computational transition states, KIEs, and branching fractions are explored to determine how solvent affects these reactions. The KIEs show that the transition state does not change significantly when the solvent is changed from dimethyl sulfoxide/methanol (a protic solvent) to dimethyl sulfoxide (a strongly polar aprotic solvent) to tetrahydrofuran (a slightly polar aprotic solvent) in the ethyl iodide-cyanide ion S(N)2 reaction in solution, as the "Solvation Rule for S(N)2 Reactions" predicts. However, the Solvation Rule fails the ultimate test of predicting gas phase results, where significantly smaller (more inverse) KIEs indicate the existence of a tighter transition state. This result is primarily attributed to the greater electrostatic forces between the partial negative charges on the iodide and cyanide ions and the partial positive charge on the alpha carbon in the gas phase transition state. Nevertheless, in evaluating the competition between S(N)2 and E2 processes, the mechanistic results for the solution and gas phase reactions are strikingly similar. The reaction of cyanide ion with ethyl iodide occurs exclusively by an S(N)2 mechanism in solution and primarily by an S(N)2 mechanism in the gas phase; only approximately 1% of the gas phase reaction is ascribed to an elimination process.

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