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Blood coagulation represents one of the most studied processes in biomedical modelling. However, clinical applications of this modelling remain limited because of the complexity of this process and because of large inter-patient variation of the concentrations of blood factors, kinetic constants and physiological conditions. Determination of some of these patients-specific parameters is experimentally possible, but it would be related to excessive time and material costs impossible in clinical practice. We propose in this work a methodological approach to patient-specific modelling of blood coagulation. It begins with conventional thrombin generation tests allowing the determination of parameters of a reduced kinetic model. Next, this model is used to study spatial distributions of blood factors and blood coagulation in flow, and to evaluate the results of medical treatment of blood coagulation disorders.

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Reduced mathematical models of blood coagulation can properly describe Thrombin Generation Test (TGT). Clot growth occurs as a reactiondiffusion wave, and the reduced model studied in this work describes this behaviour, preserving the differences observed between healthy and hemophilia subjects in the TGT. *

The paper is devoted to the investigation of a reaction-diffusion system of equations describing the process of blood coagulation. Existence of pulses solutions, that is, positive stationary solutions with zero limit at infinity is studied. It is shown that such solutions exist if and only if the speed of the travelling wave described by the same system is positive. The proof is based on the Leray-Schauder method using topological degree for elliptic problems in unbounded domains and a priori estimates of solutions in some appropriate weighted spaces.

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