Glycerol
carbonate is a useful compound of value for a variety
of cosmetic, material, and synthetic applications. Its synthesis relies
either on the carbonation of glycerol or the conversion of glycidol
by reacting it with carbon dioxide under appropriate catalytic conditions.
Here, we report the first continuous flow preparation of glycerol
carbonate using an immobilized organocatalyst (TBD@Merrifield) that
mediates the coupling of glycidol and CO2 under comparative
mild reaction and halide-free conditions. Under optimized conditions,
glycerol carbonate could be produced throughout a period of 48 h (17.3
g (147 mmol); TON, 99; productivity, 2.04 mmol h–1 mmolcat
–1) without any noticeable loss
of catalytic performance in this time frame.
A polystyrene-supported 1,5,7-triazabicyclodec-5-ene (TBD) was used as a highly recyclable and stable catalyst for the conversion of epoxy amines into various 2-oxazolidone scaffolds. This approach combines the use of CO2...
A continuous flow organocatalytic synthesis of formamides has been developed using amines and CO2 reaction partners in the presence of a silane reductant. The process is conducted under comparatively mild...
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