Several tumour biological variables not included in the seventh edition of the AJCC classification affect overall survival. These require incorporation into prognostic models to ensure a personalized approach to prognostication and treatment.
Current imaging techniques for detecting bone metastases in renal carcinoma are insensitive to small lesions. This prospective trial of 18F-NaF PET/CT shows it is more than twice as sensitive as CT and more than three times as sensitive as bone scintigraphy for these lesions. 18F-NaF PET/CT could alter management by identifying occult metastases in patients with negative standard-of-care imaging.
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