BackgroundAccurate modeling of electrostatic potential and corresponding energies becomes increasingly important for understanding properties of biological macromolecules and their complexes. However, this is not an easy task due to the irregular shape of biological entities and the presence of water and mobile ions.ResultsHere we report a comprehensive suite for the well-known Poisson-Boltzmann solver, DelPhi, enriched with additional features to facilitate DelPhi usage. The suite allows for easy download of both DelPhi executable files and source code along with a makefile for local installations. The users can obtain the DelPhi manual and parameter files required for the corresponding investigation. Non-experienced researchers can download examples containing all necessary data to carry out DelPhi runs on a set of selected examples illustrating various DelPhi features and demonstrating DelPhi’s accuracy against analytical solutions.ConclusionsDelPhi suite offers not only the DelPhi executable and sources files, examples and parameter files, but also provides links to third party developed resources either utilizing DelPhi or providing plugins for DelPhi. In addition, the users and developers are offered a forum to share ideas, resolve issues, report bugs and seek help with respect to the DelPhi package. The resource is available free of charge for academic users from URL: http://compbio.clemson.edu/DelPhi.php.

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Based on the systematic analysis of large amounts of computer-readable text, this book shows how the English language has been changing in the recent past, often in unexpected and previously undocumented ways. The study is based on a group of matching corpora, known as the 'Brown family' of corpora, supplemented by a range of other corpus materials, both written and spoken, drawn mainly from the later twentieth century. Among the matters receiving particular attention are the influence of American English on British English, the role of the press, the 'colloquialization' of written English, and a wide range of grammatical topics, including the modal auxiliaries, progressive, subjunctive, passive, genitive and relative clauses. These subjects build an overall picture of how English grammar is changing, and the linguistic and social factors that are contributing to this process.

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The web server follows a client-server architecture built on PHP and HTML and utilizes DelPhi software. The computation is carried out on supercomputer cluster and results are given back to the user via http protocol, including the ability to visualize the structure and corresponding electrostatic potential via Jmol implementation. The DelPhi web server is available from http://compbio.clemson.edu/delphi_webserver.