Lead (Pb) is a historically well-documented environmental neurotoxin that produces developmental cognitive learning and memory impairments. These early neurodevelopmental impairments cause increased brain excitability via disruption of Ca mediated signaling during critical periods of synaptogenesis inducing competition with I through NMDAs resulting in altered brain development and functioning across the lifespan. Interestingly, Pb has been shown to decrease GABA transport and uptake, decrease spontaneous and depolarization-evoked GABA neurotransmission and lower the expression of glutamic acid decarboxylase (GAD); thereby, limiting excitatory GABAergic influences that regulate early developmental brain excitability and reducing inhibition across mature GABAergic networks. Taurine has been shown to regulate brain excitability in the mature brain through GABA mediated inhibition, thereby attenuating improper brain excitability. Mechanistically, taurine is developmentally a potent neuromodulator that acts as a GABA agonist and more recently has been reported as a partial agonist for NMDAs through glycine sites. We investigated the effects of developmental Pb exposure on the rat's mature inhibitory cognitive control abilities pharmacologically through anxiety and emotional learning-related behaviors and whether taurine could recover Pb induced neurodevelopmental behavioral deficits later in life. Results showed that Pb increased anxiety symptoms in the open field and hole board test, increased sensitivity to context fear training with cognitive deficits in both acquisition and extinction learning while producing learning deficits and inabilities in acquiring inhibitory learned associations through the acoustic startle response and pre-pulse inhibition (ASR-PPI) test. Interestingly, taurine recovered Pb developmentally induced behavioral deficits in the open field and hole board test evidenced by decreased freezing and increased exploration behaviors and facilitated inhibitory dependent ASR-PPI learning to levels higher than controls. In contrast, Baclofen, a GABA agonist, dose dependently showed no interaction with Pb effects on ASR-PPI learning. Thus, taurine may work as an important neuromodulator at both GABAs and NMDAs glycine sites, thereby increasing inhibition, enhancing Ca-mediated signaling, and decreasing the altered brain excitability, which impedes learning and memory from early Pb exposure. Taken together our data suggests that GABA dependent inhibitory learning is altered by early Pb exposure and taurine was able to recover these Pb induced deficits through neuromodulation of GABAs and potentially NMDAs later in life. These findings may pave the way for further exploration of taurine as a pharmacotherapy for neurodevelopmental lead poisoning in both animal and clinical models.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.