An approach to the asymmetric synthesis of the azaphilone natural products is reported involving copper-mediated enantioselective oxidative dearomatization of o-alkynylbenzaldehydes. The approach was successfully applied to the synthesis of (-)-S-15183a and several unnatural azaphilones.

Enantioselective syntheses O 0031 Synthesis of the Azaphilones Using Copper-Mediated Enantioselective Oxidative Dearomatization. -(ZHU, J.; GRIGORIADIS, N. P.; LEE, J. P.; PORCO*, J. A. J.; J. Am. Chem. Soc. 127 (2005) 26, 9342-9343; Dep. Chem., Boston Univ., Boston, MA 02215, USA; Eng.) -Nuesgen 46-022

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