The SAr arylation of peptides with perfluoroaromatics provides a route by which to install a useful chemical handle that enables both F-NMR analysis and further chemical modification. However, chemo-selective arylation in peptides containing multiple nucleophilic side chains currently presents a challenge to the field. Herein, we demonstrate that employing 2,2,2-trifluoroethanol (TFE) as a solvent in peptide SAr reactions significantly improves nucleophile-selectivity when compared to N,N'-dimethylformamide (DMF).
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