The
merger of photoredox catalysis with transition metal catalysis,
termed metallaphotoredox catalysis, has become a mainstay in synthetic
methodology over the past decade. Metallaphotoredox catalysis has
combined the unparalleled capacity of transition metal catalysis for
bond formation with the broad utility of photoinduced electron- and
energy-transfer processes. Photocatalytic substrate activation has
allowed the engagement of simple starting materials in metal-mediated
bond-forming processes. Moreover, electron or energy transfer directly
with key organometallic intermediates has provided novel activation
modes entirely complementary to traditional catalytic platforms. This
Review details and contextualizes the advancements in molecule construction
brought forth by metallaphotocatalysis.
This tutorial review highlights the distinctive mechanistic roles of and practical considerations regarding terminal oxidants in photocatalytic “oxidase”-type reactions.
KQT-like subfamily (KCNQ) channels are voltage-gated, noninactivating potassium ion channels, and their down-regulation has been implicated in several hyperexcitability-related disorders, including epilepsy, neuropathic pain, and tinnitus. Activators of these channels reduce the excitability of central and peripheral neurons, and, as such, have therapeutic utility. Here, we synthetically modified several moieties of the KCNQ2-5 channel activator retigabine, an anticonvulsant approved by the U.S. Food and Drug Administration. By introducing a CF 3 -group at the 4-position of the benzylamine moiety, combined with a fluorine atom at the 3-position of the aniline ring, we generated Ethyl (2-amino-3-fluoro-4-((4-(trifluoromethyl)benzyl)amino)phenyl)carbamate (RL648_81), a new KCNQ2/3-specific activator that is .15 times more potent and also more selective than retigabine. We suggest that RL648_81 is a promising clinical candidate for treating or preventing neurologic disorders associated with neuronal hyperexcitability.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.