To utilize the potent pharmaceutical properties of curcumin (Cur) and gelatin-based materials in tissue regeneration, we fabricated a thermosensitive nanocomposite hydrogel based on pluronic-grafted gelatin (PG) and nanocurcumin (nCur) to enhance burn healing. In this method, the amphiphilic PG played a role as a surfactant to prepare and protect nanosized Cur particles, which could overcome the poor dissolution of the phytochemical. The synthesized PG was identified by 1 H nuclear magnetic resonance. Depending on the amount of Cur, size distribution of the dispersed nCur ranged from 1.5 ± 0.5 to 16 ± 3.2 nm as observed using transmission electron microscopy and dynamic light scattering. The nCur-dispersed PG solution formed nCur-PG nanocomposite hydrogel on warming up to 35 • C. Release profile indicated sustainable release of Cur from the injectable platform. Fibroblast cells were well proliferated on the nanocomposite hydrogel. The nCur-PG enhanced the healing process of second-degree burn wound. These results showed potential applications of the biomaterial in tissue regeneration.
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