Organometallic complexes
[Ru–Colefin(sp2)–Ru(II)–Pheox 2a–2d] containing
a Ru–Colefin(sp2) bond have been prepared
from unsaturated chiral oxazoline derivatives and evaluated for asymmetric
cyclopropanation reactions. The corresponding optically active cyclopropanes
were obtained with high yields and high stereoselectivities (≥99/<1 trans/cis, 99% trans ee).
The enantioselectivities were found to be affected by the geminal
substituent on the Ru–C(sp2) bond. In particular,
Ru(II)–Prox catalyst 2c, in which there was no
geminal substituent on the metal, was shown to have the highest enantioselectivities.
The antibacterial, antioxidant activity, and anticancer of the extract from Vernonia Amygdalina Del leaves, was assessed towards 6 selected bacteria, in the DPPH test, as well as on hepatic (HepG2), blood (K562) cancer cell lines. The DPPH assay revealed that the highest DPPH radical scavenging activity with the warm ethanol extract (IC50 = 259,03 ± 5,42 μg/mL). And the ethyl acetate extract showed a high antibacterial effect expressed as minimum inhibitory concentration (MIC = 100 mg/mL) against Gram-positive bacteria. At the concentration of 250 mg/mL, this extract also demonstrated its ability to resist blood cancer cells K562 (with a survival rate of 25%) and liver cancer cells HepG2 (with a survival rate of 0%).
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