To conduct a clinical biochemical study that aids in investigation of some non-coding RNA expressions and polymorphisms (including long non-coding RNAs and miRNAs) namely, MALAT-1 and miR-9 in attempt to provide new diagnostic biomarkers in vitiligo patients for Egyptians. Twenty patients having vitiligo and other twenty apparently controls were included in this study. Serum and biopsy were taken where patients were classified into lesional and peri-lesional groups. Laboratory and pathological investigations were assessed. Serum miR-9 and long-non coding MALAT-1 were measured. Vitiligo patients had a mean age of 36.40±13.75. The mean serum miR-9 level in patients group (4.28 ± 1.70) was significantly higher than in the control (1.05 ± 0.12) (p = 0.001). The MALAT-1 level in vitiligo patients was (3.65 ± 1.30) significantly higher than control (1.45 ± 0.15) (p = 0.001). There was a positive association between the expression levels of MALAT-1and miR-9in serum and tissue as well where p-value <0.05. miR-9 as well as long non-coding MALAT-1 may be considered as biomarkers for vitiligo susceptibility which may provide a new direction for treatment.

Background: Female genital mutilation (FGM) is a procedure that had physical, social, psychological, and sexual complications. The study aimed to assess effect of FGM on couple sexual function.Methods: case control nested from cross-sectional study in Fayoum governorate; it was conducted during a period of five months (March 2016 to July 2016).Results: The prevalence of FGM was 432(83.4%). The risk of exposure to mutilation was about four folds higher among women inhabitant rural areas, and about nine folds higher among low educated women, and around six folds higher if parents were low educated. Around one-third of women in the study 157 (30.3%) suffered psychological problems and 142 (27.4%) of them suffered marital and social problems related to FGM practice. Mutilated women had five folds decrease in desire: four folds decrease in sexual satisfaction and five folds increase in sexual dysfunction on contrary 57% to 59% decrease in arousal and orgasm. As regards to husband sexual satisfaction, it decreases by around three folds if their wives were mutilated. There is statistically a significant increase in couple sexual dysfunction among complicated mutilation.Conclusions: FGM is still practiced in Egypt and it resulted in many physical, psychological, and social complications; also it had a negative impact on the couple's sexual life.