This study demonstrated that carriers of the ApoE ɛ4 polymorphism genotype show demonstrable improvement in VA after treatment with ranibizumab in exudative AMD. ApoE polymorphism identification may be used as a genetic screening to tailor individualized therapeutic approach for optimal treatment in neovascular AMD.

The class of generalized linear models is an extension of traditional linear models that allows the mean of the response variable to be linearly dependent on the explanatory variables through a link function. Generalized linear models allow the probability distribution of the response variable to be a member of an exponential family of distributions. The exponential family of distributions include many common discrete and continuous distributions such as normal, binomial, multinomial, negative binomial, Poisson, gamma, inverse Gaussian, etc. Also link functions can be built as identity, logit, probit, power, log, and complementary log-log link functions. In this study, supply, transformation and consumption, imports and exports of solid fuels, oil, gas, electricity, and renewable energy annual data of European Union countries between 2005 and 2013 years are investigated by using generalized linear models. In this case, the response variable is taken as annual complete energy balances of European Union countries as a continuous variable having positive values, and the distribution of the response variable comes from the gamma distribution with log-link function.

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Abstract:In the concept of the aesthetic formation of knowledge and its as soon as possible and success-oriented application, insights and profits without the reference to the arguments developed around 1900. The main investigation also includes the period between the entry into force and the presentation in its current version. Their function as part of the literary portrayal and narrative technique. Keywords: Function, transmission, investigation, principal, period Dedicated to Paul Placeholder Studies and InvestigationsThe main investigation also includes the period between the entry into force and the presentation in its current version. Their function as part of the literary portrayal and narrative technique. Abstract:Energy security is one of the major components of energy sustainability in the world's energy performance. In this study, energy security is taken as an ordinal response variable coming from the multinomial distribution with the energy grade levels A, B, C, and D. Thereafter, the world energy security data is tried to be statistically modelled by using generalized linear model (GLM) approach for the ordinal response variable under different cumulative link functions. The cumulative link functions comparatively used in this study are cumulative logit, cumulative probit, cumulative complementary log-log, cumulative Cauchit, and cumulative negative log-log. In order to avoid a multicollinearity problem in the data structure, principal component analysis (PCA) technique is integrated with the GLM approach for the ordinal response variable. In this study, statistically, the importance of determining the best cumulative link function on the accuracy of parameter estimates, confidence intervals, and hypothesis tests in the GLM for the multinomially distributed response variable is highlighted. In terms of energy evaluation, by using cumulative logit as the best cumulative link function, energy sources consumptions, electricity productions from nuclear energy, natural gas, oil, coal, and hydroelectric, energy use per capita and energy imports are found to have statistically significant effects on energy security in the world's energy performance.

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