Background and Aims Coronary artery disease is high‐risk comorbidity of COVID‐19 infection. Nonelective coronary artery revascularization in COVID‐19 patients carries substantial risk. Therefore, it is essential to understand the risk factors and outcomes fully. This study aims to evaluate the prognosis of coronary artery bypass grafting (CABG) surgery in patients with COVID‐19. Methods This retrospective cohort study assesses 171 patients who underwent urgent and emergent CABG in Tehran Heart Center from March 2020 to September 2021. The patients were allocated to cases and controls based on COVID‐19 infection status. Demographic and clinical features, alongside the complications and outcomes, were compared between the two groups. Results According to diagnostic criteria, 62 patients were diagnosed with COVID‐19 (Case) and 109 patients had no COVID diagnosis (Control). Regarding the demographics and risk factors, hypertension was more prevalent among patients with COVID‐19 (64.5% compared to 43.1% p = 0.007). Length of hospital stay, ventilation time, and intensive care unit (ICU) stay time were significantly higher in patients infected with COVID‐19. Postoperative complications, including stroke, atrial fibrillation, pleural effusion, blood transfusion, and Inotrope use, were significantly higher in the case group. Mortality rates were also higher in COVID‐19 patients with an odds ratio of 1.53; however, this difference is not statistically significant ( p : 0.44, 95% CI = 0.50–4.01). Conclusion COVID‐19 is associated with a significantly higher hospital stay, ventilation time, and ICU stay. Mortality rates are also higher, albeit insignificantly. Various postoperative complications are also higher with COVID‐19.
Background: Flat foot is a deformity in which patients lack standard arches in the soles of the foot. Flat foot improves with age. This study was designed to determine the prevalence of flexible flat foot among male school children in Tehran, Iran. Methods: A total of 1539 male school children were included in this study. Students were examined for the flatness of the sole of the foot as well as its degree and type. Flat foot was diagnosed on inspecting a poor formation of the arch. The severity of flatness was classified according to Denis criteria. Results: Among 1512 children whose foot condition was recorded, 80.7% had normal/grade 1 sole, 16.7% had 2nd degree flat feet, and 2.6% had 3rd degree flat feet. Prevalence of genu varum was 16.1% and prevalence of genu valgum was 2.7% (P = 0.504). The prevalence of flat foot decreased significantly with age; in the group of 11-year-old boys and younger, 23.1% showed a grade 2 and grade 3 flat foot, whereas in the group of 12-year-old boys and older, only 13.6% hada grade 2 and grade 3 flat foot (P < 0.001). Conclusion: In this study, a significant relationship was found between weight gain and body mass index (BMI) with flat feet. There is a significant association between passing the age of 12 years and a decrease in flat foot. Also, the association between flat foot with weight and height of children was examined separately, and it was found that weight could significantly be a poor predictor of flat feet.
Background: This study was designed to achieve a new method as a preventive treatment for complications of growth plate fractures. In this study, we investigate the effect of intra-articular injection of anti-vascular endothelial growth factor (anti-VEGF) antibody bevacizumab on the repair process of articular cartilage in a type 4 Salter Harris injury model. Methods: A Salter Harris injury was created on the proximal tibial growth plate of 14 rats by a 1.8 mm drill. The rats were randomly classified into two groups: group LD, administration of high-dose intra-articular injection of bevacizumab (250 μg), and group HD, administration of low-dose intra-articular injection of bevacizumab (50 μg) after injury. The rats were killed 2 months postoperatively and their tibia underwent micro-computed tomography (CT) analysis, histological assessment, and measurement of tibial bone length. Results: Bony bar formation was observed in 71% of the samples in the high-dose group and in 100% of the low-dose group. Relative increase in physeal cartilage thickness (P = 0.007) and decrease in bony bar formation (P = 0.029) were observed significantly in the high dose group. There was no significant difference in tibia length between the two groups (P = 0.150). Conclusion: Intra-articular administration of bevacizumab demonstrated positive restorative effects. We suggest this method of treatment due to its potential of improving cartilage repair and capability to be used as a main or adjacent treatment in osteochondral defects.
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