Objective: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer treatment. There is no proven pharmacological application to prevent CIPN. This study was conducted to compare the effects of cold application and exercise on peripheral neuropathy development in patients with breast cancer who received taxane. Methods: This was a multicenter clinical trial. The study was conducted as a randomized controlled trial on breast cancer patients who had chemotherapy-induced peripheral neuropathy complaints between July 2017 and January 2018 in an outpatient chemotherapy unit of training-research and a university hospital. A standardized, home-based, 12-week exercise program involved progressive strengthening, stretching, and balance exercises. Cold packs were applied for the duration of all 12 taxane infusions and then continued at home. The standard care protocol (information about side effects) of the clinic was used for patients in the control group. Data were collected via Patient Identification Form and CIPN Assessment Tool. Demographic data were evaluated by number and percentage ratios, and the study groups' mean scores were compared by Kruskal–Wallis and Wilcoxon analyses. The data were collected at two time points including baseline (T1) and week 12 (T2). Results: The study was completed with a total of 90 patients, so that each of the study groups, exercise, cold application, and control groups, included 30 patients. The mean of pre- and posttest results in the cold applied group revealed an increase in hand numbness, weakness, and distress ( P < 0.05). However, no significant difference existed between the means of the pre- and the posttests in the exercise group ( P = 0.79–0.1). The mean scores of all the symptoms in the control group except the loss of balance increased significantly ( P < 0.05). Exercise reduced CIPN symptoms of numbness in hands ( P = 0.009) and in the feet ( P = 0.005) significantly compared to the cold application and control. Conclusions: It was found that exercise was more effective than cold application in the management of CIPN.
Objective:The aim was to evaluate the reliability and the validity of the Turkish version of the chemotherapy-induced peripheral neuropathy assessment tool (CIPNAT) in cancer patients using taxane.Methods:This methodological study was carried out to evaluate the validity and the reliability of the CIPNAT. The sample cohort comprised 430 breast cancer patients who were administered taxane, a chemotherapeutic agent, between April and December 2017. Data were collected by the CIPNAT and by a demographic data form. The CIPNAT content reliability was checked after completing it in Turkish. Validity was tested after the translation as well. Cronbach's alpha and test–retest reliability were utilized for reliability analyses.Results:Cronbach's alpha value was 0.87 in this study. The test–retest reliability ranged between 0.90 and 0.96 for all items. No difference existed between the means of test and retest scores of the CIPNAT. A statistically significant positive relationship materialized between the item's test and retest scores. There were statistically significant positive relationships among all levels of the CIPNAT. Factor analysis resulted in a size value higher than 1 and explained 66% of total variation. These results show that the Turkish version of the CIPNAT is a valid and reliable scale in Turkish society.Conclusions:This study showed that the CIPNAT in Turkey is a reliable and valid tool to evaluate taxane chemotherapy in breast cancer patients.
<b><i>Aim:</i></b> This study was conducted in a randomized controlled manner to evaluate the effect of reflexology on nausea, vomiting, and anxiety due to taxane group chemotherapeutics in patients with breast cancer. <b><i>Method:</i></b> The study was conducted in the Daytime Chemotherapy Unit of Gülhane Training and Research Hospital and Ankara Training and Research Hospital from June 28 to December 20, 2019, with intervention (<i>n</i> = 29) and control (<i>n</i> = 29) groups. Data were collected using the Patient Information Form, the Rhodes Index of Nausea, Vomiting and Retching, and the Spielberger State-Trait Anxiety Inventory. Patients in the intervention group received reflexology for a total of 6 weeks, once a week. The patients in the control group did not receive any treatment other than the routine maintenance of the chemotherapy unit. <b><i>Result:</i></b> As a result, it was determined that 40% of all patients were 55 years or older. While nausea was observed in all patients in the intervention and control groups, vomiting was not noted in the vast majority of patients. Regarding the effect of reflexology on nausea and vomiting, although the mean scores of nausea, vomiting and retching experience, occurrence and distress in both groups were lower than the initial measurement, there was no difference between the groups. Based on the research findings, the State and Trait Anxiety mean scores in the intervention group decreased significantly, while they increased in the control group. <b><i>Conclusion:</i></b> The research showed that while reflexology did not affect nausea and vomiting in breast cancer patients receiving chemotherapy, it was helpful in reducing anxiety.
Objectives: The first phase of the COVID-19 vaccine was launched in Turkey in January 2021 and was intended primarily for healthcare workers. Vaccine side effects play important role in building public confidence in vaccination. This study aims to determine the early-stage vaccine side effects in healthcare workers who have been given the COVID-19 vaccine. Methods: The research has a descriptive cross-sectional type of design. The data were collected face-to-face with the questionnaire form created by the researchers, which investigated the sociodemographic characteristics and vaccine complications of the participants. Results: The sample of the study consisted of 321 medical personnel (%55.6 female, %79.8 under 40 years, %67.1 nurses, %15.2 physicians, and %17.4 laboratory workers) who received the Covid-19 vaccine in Turkey and voluntarily agreed to participate in the study. The most common side effects associated with vaccination were as follows: pain (%46.3 Sinovac, %55.5 Pfizer- biotech), heat increase (%32.8 Sinovac, %30.7 Pfizer- biotech), whole-body aches (%55.2 Sinovac, %58.7 Pfizer- biotech) and injection site redness (%28.4 Sinovac, %26.0 Pfizer- biotech). Conclusions: The benefits of the Covid-19 vaccine outweigh its identified side effects of it. Most of the side effects reported in this study were consistent with Pfizer-Biotech.
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