The asymmetric aziridination of cyclic enones with N-tosyloxycarbamates, using N-neopentyl 1,2-diphenylethylenediamine as a catalyst, and its application to the formal total synthesis of (-)-agelastatin A, using a one-pot silylation-selenylation procedure and the regioselective aziridine-opening by an azide anion as key steps, are described.
We used enflurane for maintenance anesthetic during induced hypothermia in 9 cases of intracranial operations. Anesthesia was induced with thiopental and maintained with enflurane and nitrous oxide. Ventiration was controlled with a respirator. With administration of Triflupromazine 0.78-1.36mg/kg, hypothermia was induced by surface cooling technique. During hypothermia enflurane concentration was maintained between 0.4 and 0.8%. Throughout the course of hypothermic anesthesia there were no severe arrythmias or no metabolic acidosis, and the cotrol of intracranial pressure was satisfactory. We are impressed by the fact that in this method hemodynamics is stable and the return of consciousness takes short time. This method will be usefull for neurosurgical operations of vascular rich tumors.
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