Schizophrenia is a complex disorder whose etiology and pathogenesis is not completely understood. Schizophrenia is associated with increased activity at dopaminergic and serotoninergic receptor sites [1,2]. Dopamine D 2 occupancy is most important and required for an antipsychotic response. However, it has been proven that, extrapyramidal side effects are also increased with the increase of dopamine receptor occupancy above 80 % [3]. Some antipsychotic drugs like clozapine, olanzapine (fig. 1) have lower dopamine D 2 occupancy with faster dissociation from the receptor [4-6]. The newer atypical antipsychotics compounds have interaction with multiple receptor targets. These drugs act through blockade of several receptors like dopamine, serotonin (5HT), adrenergic, muscarinic and histamine receptors [7,8]. In the atypical antipsychotic activity, 5HT receptor acts as an important target [9]. The atypical antipsychotic agents possess 5HT 2A antagonistic activity along with D 2 receptor antagonistic activity and these targets are the basis for the design of newer potential atypical antipsychotic agents. These potential atypical antipsychotic agents have fewer side effects [10-12]. These new potential antipsychotics will provide knowledge about the molecular mechanisms of action and is important for understanding of the pathophysiology of schizophrenia and for design of new drugs with improved efficacy and fewer side effects than the existing ones. The aim of present work was to synthesize new molecule like chromen-2-one derivatives, which might act on D 2 receptors as well as 5HT receptor and evaluate their pharmacological action for atypical antipsychotic activity.
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