Research aims to review 21st century skills in-based senior high school chemistry learning virtual labs. The components that will be studied include: (1) Barriers to high school chemistry learning; (2) 21st century skills; (3) The advantages and disadvantages of using virtual labs; and (4)implications of virtual labs on 21st century skills. The method used in writing the article is descriptive, qualitative by analyzing national and international articles related to 21st century skills in-based high school chemistry learning virtual labs. The results show that high school chemistry learning uses virtual The lab can integrate 21st century skills, visualize abstract concepts into concrete, support student-centered learning, reduce anxiety in facing real laboratories, and increase students' self-efficacy so that they can become a capable supporting unit for the chemistry learning process. However, in its implementation it needs to be adapted to content and activities that refer to various aspects of 21st century skills.

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Penelitian ini bertujuan untuk mengetahui kandungan fitokimia dan menentukan kadar toksisitas dari ekstrak daun paku sisik naga (D.Pilloselloides) yang terdapat di kawasan Universitas Mulawarman. Ekstrak dibuat menggunakan cara maserasi menggunakan pelarut metanol dan n-heksan. Uji toksisitas dilakukan dengan metode BSLT menggunakan larva udang Artemia salina yang telah dipelihara hingga berumur 48 jam. Uji fitokimia pada ekstrak daun paku sisik naga fraksi metanol menunjukkan adanya alkaloid, flavonoid, saponin, steroid, dan fenolik. Sedangkan untuk fraksi n-heksan terdapat kandungan alkaloid dan steroid. Hasil uji toksisitas menunjukkan ekstrak daun paku sisik naga bersifat toksik dengan nilai LC50 dari fraksi metanol dan fraksi n-heksan berturut-turut adalah 44,67 ppm dan 239,88 ppm.