Executive functions deficits are among the most frequently reported symptoms of autism spectrum disorders (ASDs), however, there have been few functional magnetic resonance imaging (fMRI) studies that investigate the neural substrates of executive functions deficits in ASDs, and only one in adolescents. The current study examined cognitive control -the ability to maintain task context online to support adaptive functioning in the face of response competition-in 22 adolescents aged 12-18 with autism spectrum disorders and 23 age, gender, and IQ matched typically developing subjects. During the cue phase of the task, where subjects must maintain information online to overcome a prepotent response tendency, typically developing subjects recruited significantly more anterior frontal (BA 10), parietal (BA 7, 40), and occipital regions (BA 18) for high control trials (25% of trials) versus low control trials (75% of trials). Both groups showed similar activation for low control cues, however the ASD group exhibited significantly less activation for high control cues. Functional connectivity analysis using time series correlation, factor analysis, and beta series correlation methods provided convergent evidence that the ASD group exhibited lower levels of functional connectivity and less network integration between frontal, parietal, and occipital regions. In the typically developing group, fronto-parietal connectivity was related to lower error rates on high control trials. In the autism group, reduced fronto-parietal connectivity was related to attention deficit hyperactivity disorder symptoms.

Cognitive control refers to the ability to flexibly allocate mental resources to guide thoughts and actions in light of internal goals. Given the behavioral inflexibility exhibited by individuals with autism spectrum disorders (ASDs), it would appear they experience cognitive control deficits. Cognitive correlates of this behavioral inflexibility have been elusive in previous investigations. Study goals were to investigate deficits in cognitive control in ASDs; to explore its developmental trajectory; and to test whether control deficits are related to symptoms of inflexible thoughts and/or behaviors, and attention symptoms. Thirty-one children and adolescents aged 8-17 with ASDs and 32 age, IQ, and gender matched control subjects completed cognitive, diagnostic, and behavorial assessments, as well as a measure of cognitive control involving overcoming a prepotent response tendency. Compared with typically developing control subjects, individuals with ASDs exhibited deficits in cognitive control. Younger children with ASDs did not demonstrate age-related improvements in cognitive control. Modest relationships between cognitive control, IQ, and attention problems were found for the sample. Only the relationship between cognitive control and full-scale IQ survived correction for multiple comparisons.

Evaporation can be determined by the aid of the first law of thermodynamics in such a way that wind velocity need not enter the calculation. Air temperature and humidity enter only as terms in a correction which can have a relatively small average value under typical conditions. The complete equation is E = (H-S~C)/L(l+R)where E is the evaporation, H the difference between the incoming and outgoing radiation, S the heat stored in a column of water having unit cross-section, C a correction for heat carried by flowing water and leakage of heat through the walls of the vessel, L the latent heat of water, and R is Bowen's ratio. A method of finding the difference between the incoming and outgoing radiation, by means of observations on a well insulated pan is described, and also a method of finding the ratio of sensible heat to latent heat transmitted through the air-water surface. Bowen's theoretical conclusions respecting this ratio were found to be consistent with observations. The above formula can be used in estimating evaporation from an actual lake whenever the requisite data can be obtained. Although from a physical standpoint the quantity of sensible heat passing through the air-water surface is not strictly negligible, nevertheless is most meteorological and engineering applications, the error caused by neglecting this quantity will be negligible in comparison with other errors that enter the main problem of which evaporation is a part.

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