Background: To date, although neonatal infections with severe acute respiratory syndrome coronovirus 2 (SARS-CoV-2) have been described, none of these have been proven to be the result of vertical transmission of SARS-CoV-2. Methods: We describe the probable vertical transmission of SARS-CoV-2 in a neonate born to a mother with coronavirus disease 2019 (COVID-19). Results: Following cesarean section, the neonate was kept in strict isolation. Molecular tests for SARS-CoV-2 on respiratory samples, blood, and meconium were initially negative, but positive on a nasopharyngeal aspirate on the third day of life. On day 5, the neonate developed fever and coryza, which spontaneously resolved. Viral genomic analysis from the mother and neonate showed identical sequences except for 1 nucleotide. Conclusion: This report has important implications for infection control and clinical management of pregnant women with COVID-19 and their newborns.
is an anaerobic gram-positive organism associated with genitourinary infections. Bacteraemia is rare, with only two cases reported in the literature. This case describes an 18-year-old type 1 diabetic, presenting with sepsis and haemoptysis, on a background of poor dental hygiene and recurrent hospital admissions. Blood cultures grew and echocardiogram revealed a large tricuspid valve lesion. Despite medical therapy, symptoms of pulmonary emboli continued and she therefore underwent surgical resection of the lesion. Histopathological findings were of a vegetation; culture of the lesion was negative but 16S ribosomal PCR was positive, detecting 16S rRNA of The patient was treated with 4 weeks of vancomycin and made a good recovery. To our knowledge, this represents the first report of infective endocarditis due to this organism. We also provide a review of the literature, including comparing published drug susceptibility data with consensus breakpoints for antimicrobial agents.
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a serious reaction to drugs with a clinical presentation of rash, fever, lymph node enlargement and internal organ involvement. Reports have described the reactivation of human herpes virus 6 (HHV-6) and other HHVs in association with this syndrome. We report a 41-year-old woman who developed a rash, fever, liver dysfunction, eosinophilia and atypical monocytosis 21 days after initiation of the quadruple therapy for tuberculous cervical lymphadnitis. HHV-7 DNA was detected in blood by PCR suggesting infection with or more likely reactivation of HHV-7 as a contributing factor or consequence of this serious adverse drug reaction.
Abstract:Introduction: Dysfunction, degeneration, and loss of retinal pigment epithelial (RPE) cells are prominent features of subtypes of retinitis pigmentosa (RP) which is a cause of visual disability. In this condition, there is progressive visual loss that often leads to blindness. A variety of therapeutic approaches to delay the degenerative process are under development, the most promising of which is the stem cell regenerative therapy. Stem cells are self-renewing cells capable of transdifferentiation into a number of cell lineages. Mesenchymal stem cells (MSCs) represent a type of stem cell with remarkable proliferative, regenerative and transdifferentiation ability. Aim of the Work: The aim of this work was to evaluate the ability of bone marrow derived MSCs to differentiate into retinal pigmented epithelial cells in vitro as a step towards regeneration of degenerated retinal cells as in cases of retinitis pigmentosa. Patients and Methods: The present study was carried out on 20 bone marrow samples obtained from donors undergoing bone marrow aspirations, at EL-Maadi Military Hospital. 3 ml bone marrow were aspirated, mesenchymal stem cells were separated and induced to RPE lineage through culture in the presence of nicotinamide NIC and factors from the TGF-b superfamily (Activin A). The BMSC-derived pigmented-like cells were evaluated for the morphology, function, and marker expression of authentic RPE using RT-PCR for RPE65 mRNA. Results: Bone marrow derived mesenchymal stem cells in all samples demonstrated the morphologic characteristics as well as molecular markers of RPE cells after 8 weeks of culture with activin A and nicotinamide. Conclusion: In the present study, compelling evidences support the possibility of differentiation of bone marrow stem cells into retinal pigmented epithelial cells (RPE) which have the morphology, function, and marker expression of authentic RPE.
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