Significant advancements in C−N bond formation via C−H bond functionalisation have made it a staple in the production of nitrogen-containing compounds in both industry and academia. However, transition metal-free synthesis,...
Macroscopic, endomicroscopic, and histologic findings and correlation are an integral part of the diagnostic evaluation of pancreatic cystic lesions (PCLs), as complementing morphologic features seen by different specialties are combined to contribute to a final diagnosis. However, malignancy risk stratification of PCLs with worrisome features can still be challenging even after endoscopic ultrasound guided-fine needle aspiration (EUS-FNA) with cytological evaluation. This review aims to summarize cyst clinicopathological features from the pathologists’ perspective, coupled with knowledge from advanced diagnostics–confocal laser endomicroscopy and cyst fluid molecular analysis, to demonstrate the state-of-art risk stratification of PCLs. This review includes illustrative photos of surgical specimens, endomicroscopic and histologic images, and a summary of cyst fluid molecular markers.
With an ever-growing emphasis on sustainable synthesis, aerobic C–H activation (the use of oxygen in air to activate C−H bonds) represents a highly attractive conduit for the development of novel...
Herein, we report the transformation of readily accessed
acyl hydrazides
into protected 2-aminobenzophenones via a two-step process involving
an aryne-based molecular rearrangement followed by a one-pot addition–elimination
procedure. The assembly of the scaffold is tolerant of a wide variety
of functional groups, and the carbamate group on the product can be
facilely removed to afford highly valuable 2-aminobenzophenones. Application
of the protocol was demonstrated in the synthesis of neurological
medicine phenazepam.
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