A metal-free visible-light-induced trifluoromethylation
of Bunte
salts of α-bromoketones/alkyl bromide/benzyl bromides/functionalized
allyl (Baylis–Hillman) bromides has been accomplished using
Langlois’ reagent in the presence of inexpensive eosin Y as
a photocatalyst to form the privileged trifluoromethylthiolated synthons.
The method is straightforward, operationally simple, and endowed with
broad substrate scope and good functional group tolerance.
A practical synthesis of new β-difluoromethoxy vinyl sulfones has been explored by O-difluoromethylation of β-ketosulfones using inexpensive and easily workable sodium chlorodifluoroacetate as a difluorocarbene precursor. The strategy is convenient,...
An efficient synthesis of alkenylated imidazo[1,2-a]pyridines has been accomplished using imidazo[1,2-a]pyridines and α,β-unsaturated carboxylic acids adopting C-H functionalization strategy in the presence of palladium acetate, 1,10-phenanthroline, and silver carbonate.
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