BackgroundBreast cancer is by far the most frequent cancer of women. It is the second leading cause of death in women worldwide. Approximately one out of eight women develops breast cancer all over the world. Majority of cases of cancer of the breast are detected by women themselves, stressing the importance of breast self-examination. The main objective of this study was to assess predictors of breast self-examination among female teachers in Kafa Zone, South West part of Ethiopia.MethodsA cross-sectional study was conducted among randomly selected 315 female teachers. Self administered a structured questionnaire including socio-demographic characteristics, knowledge about breast cancer and perception of teachers on breast self examination using the Champion’s revised Health Belief Model sub scales used as data collection instrument. Multivariable logistic regression analyses were used to identify independent predictors of breast self -examination performance.ResultThree hundred and fifteen female teachers were participated in this study. Their mean age was 33 SD [±7] years. Only 52 (16.5 %) participants ever heard about breast self examination and from those who heard about breast self examination 38 (73.07 %) of them ever performed breast self examination. After controlling for possible confounding factors, the result showed that knowledge towards breast self examination, perceived susceptibility, perceived severity and the net perceived benefit were found to be the major predictors of breast self examination.ConclusionThis study revealed that breast self examination performance among female teachers was very low. Therefore, behavior change communication and interventions that emphasize different domains that increase the perceived threat to breast cancer as well as on the benefits of breast self-examination to increase the perception of the teachers in an integrated manner may be the most effective strategies that should be considered by the health offices and educational offices. These may help to increase the knowledge and skill of female teachers on how to perform breast self-examination and its importance hence helpful for wider of the community.