BackgroundThe health sector has quickly become a target for cyberattacks. Hospitals are especially sensitive to these sorts of attacks as any disruption in operations or even disclosure of patient personal information can have far-reaching consequences. The objective of this study was to map the available literature on cyberattacks on hospitals and to identify the different domains of research, while extracting the recommendations and guidelines put forth in the literature.MethodsFour databases (PubMed, Web of Science, ProQuest, and Scopus) were searched using standardized and adapted search syntax in order to identify relevant manuscripts published between 1997 and 2017. These were screened by two reviewers and included or excluded based on inclusion and exclusion criteria. Data from articles were then extracted and analyzed.ResultsThe search identified 818 records of which 97 were included. Of the 97, 32% were published in 2017 while around 40% of the articles were published prior to the last three years. Six domains of research emerged through the analysis, which are included here: context and trends in cybersecurity (27.8%), connected medical devices and equipment (29.9%), hospital information systems (14.4%), raising awareness and lessons learned (6.2%), information security methodology (15.4%), and specific types of attacks (6.2%).ConclusionThere is a generally growing interest in the research field, but the available literature remains limited in number. There are important aspects of cybersecurity (e.g. cloud storage and access management) as well as specific medical fields that rely on various medical devices that have been neglected. Recommendations are available, but comprehensive guidelines and standardized best practice measures are still necessary.Electronic supplementary materialThe online version of this article (10.1186/s12911-018-0724-5) contains supplementary material, which is available to authorized users.

ObjectivesPrecision medicine (PM) aims to improve patient outcomes by stratifying or individualizing diagnosis and treatment decisions. Previous reviews found inconclusive evidence as to the cost-effectiveness of PM. The purpose of this scoping review was to describe current research findings on the cost-effectiveness of PM and to identify characteristics of cost-effective interventions. MethodsWe searched PubMed with a combination of terms related to PM and economic evaluations and included studies published between 2014 and 2017. ResultsA total of 83 articles were included, of which two-thirds were published in Europe and the USA. The majority of studies concluded that the PM intervention was at least cost-effective compared to usual care. However, the willingness-to-pay thresholds varied widely. Key factors influencing cost-effectiveness included the prevalence of the genetic condition in the target population, costs of genetic testing and companion treatment and the probability of complications or mortality.ConclusionsThis review may help inform decisions about reimbursement, research and development of PM interventions.Electronic supplementary materialThe online version of this article (10.1007/s00038-019-01298-x) contains supplementary material, which is available to authorized users.

BackgroundThe 2014-2016 Ebola outbreak across West Africa was devastating, acting not only as a wake-up call for the global health community, but also as a catalyst for innovative change and global action. Improved infectious disease monitoring is the stepping-stone toward better disease prevention and control efforts, and recent research has revealed the potential of digital technologies to transform the field of global health. This scoping review aimed to identify which digital technologies may improve disease prevention and control, with regard to the 2014-2016 Ebola outbreak in West Africa.MethodsA search was conducted on PubMed, EBSCOhost and Web of Science, with search dates ranging from 2013 (01/01/2013) – 2017 (13/06/2017). Data was extracted into a summative table and data synthesized through grouping digital technology domains, using narrative and graphical methods.FindingsThe scoping review identified 82 full-text articles, and revealed big data (48%, n = 39) and modeling (26%, n = 21) technologies to be the most utilized within the Ebola outbreak. Digital technologies were mainly used for surveillance purposes (90%, n = 74), and key challenges were related to scalability and misinformation from social media platforms.InterpretationDigital technologies demonstrated their potential during the Ebola outbreak through: more rapid diagnostics, more precise predictions and estimations, increased knowledge transfer, and raising situational awareness through mHealth and social media platforms such as Twitter and Weibo. However, better integration into both citizen and health professionals’ communities is necessary to maximise the potential of digital technologies.

Throughout recent years, we have witnessed an increase in human migration as a result of conflict, political instability and changes in the climate. Despite the growing number of migrants and refugees, provisions to address their health needs remain inadequate and often unmet. Whilst a variety of instruments exist to assert and emphasise the importance for migrant and refugee health, the lack of shared priorities between partners and stakeholders results in poor access to healthcare and essential medicines.In response to the growing health challenges faced by migrants and refugees, members of the M8 Alliance launched an annual Expert Meeting on Migrants’ and Refugees’ Health. This report is shaped by discussions from the second M8 Alliance Expert Meeting (Sapienza University of Rome, Italy, 15–16 June 2018) and is supported by supplementing literature to develop a framework addressing critical reflections, challenges and solutions of and for migrant and refugee health. This report aims to inform decision-making fostering a humanitarian, ethics and rights-based approach. Through a series of country-specific case studies and discussions, this report captures the most prominent themes and recommendations such as mental health, tuberculosis (TB) and best practices for increased access.

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