In the title compound, C24H20ClNO2, the mean planes of 4-chlorophenyl, 2-methylphenyl and phenylene rings make dihedral angles of 62.8 (2), 65.1 (3) and 15.1 (2)°, respectively, with the 5-methyl-1,2-oxazole ring. In the crystal, molecules are linked by intermolecular C—H...N, C—H...Cl, C—H...π contacts and π–π stacking interactions between the phenylene groups. Hirshfeld surface analysis indicates that the most important contributions to the crystal packing are from H...H (48.7%), H...C/C...H (22.2%), Cl...H/H...Cl (8.8%), H...O/O...H (8.2%) and H...N/N...H (5.1%) interactions.
Study of the anti(myco)bacterial and antitumor activities of prolinate and N-amidocarbothiolprolinate derivatives based on fused tetrahydropyrrolo[3,4c]pyrrole-1,3(2H,3aH)-dione, bearing an indole ring
The aim of the study is to explore the crystal structure and performe Hirshfeld surface analysis of 1-(4-chlorophenyl)-5-{4-[(2-methylphenyl)methoxy]phenyl}-1H-pyrazole.In the title compound, C23H19ClN2O, the 4-chlorophenyl, 2-methylphenyl and benzene rings are oriented with dihedral angles of 71.22(10), 31.82(9) and 59.76( 9)°, respectively, with respect to the pyrazole ring. Pairs of molecules are linked by intermolecular C-H•••O hydrogen contacts with R 2 2(8) ring motifs forming sheets lying parallel to (100). Furthermore C-H•••π interactions also contribute to stabilizing the molecular packing. A Hirshfeld surface analysis has been used to confirm and quantify the supramolecular interactions which indicate that the most important contributions for the crystal packing are from H•••H (42.5%) and H•••C/C•••H (35%) and H•••Cl/Cl•••H (12%) interactions.
The molecular conformation is stabilized by an intramolecular O—H⋯N hydrogen bond. In the crystal, molecules are linked by C—H⋯O hydrogen bonds, forming wave-like layers. C—H⋯π interactions involving the benzene rings and the methylene hydrogen atoms of the morpholine rings are observed between the layers.
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