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Motivated by problems in molecular biosciences wherein the evaluation of entropy of a molecular system is important for understanding its thermodynamic properties, we consider the efficient estimation of entropy of a multivariate normal distribution having unknown mean vector and covariance matrix. Based on a random sample, we discuss the problem of estimating the entropy under the quadratic loss function. The best affine equivariant estimator is obtained and, interestingly, it also turns out to be an unbiased estimator and a generalized Bayes estimator. It is established that the best affine equivariant estimator is admissible in the class of estimators that depend on the determinant of the sample covariance matrix alone. The risk improvements of the best affine equivariant estimator over the maximum likelihood estimator (an estimator commonly used in molecular sciences) are obtained numerically and are found to be substantial in higher dimensions, which is commonly the case for atomic coordinates in macromolecules such as proteins. We further establish that even the best affine equivariant estimator is inadmissible and obtain Stein-type and Brewster-Zidek-type estimators dominating it. The Brewster-Zidek-type estimator is shown to be generalized Bayes. r

Allocation of a redundant component in a system in order to optimize, in some sense, the lifetime of the system is an important problem in reliability theory, having practical applications. Consider a series system consisting of two components (say C1 and C2), having independent random lifetimes X1 and X2, and suppose a component C having random lifetime X (independent of X1 and X2) is available for active redundancy with one of the components. Let U1 = min(max(X1, X), X2) and U2 = min(X1, max(X2, X)), so that U1 (U2) denote the lifetime of a system obtained by allocating C to C1 (C2). We consider the criterion where C1 is preferred to C2 for redundancy allocation if . Here we investigate the problem of allocating C to C1 or C2, with respect to the above criterion. We also consider the standby redundancy for series and parallel systems with respect to the above criterion. The problem of allocating an active redundant component in order that the resulting system has the smallest failure rate function is also considered and it is observed that unlike stochastic optimization, here the lifetime distribution of the redundant component also plays a role, making the problem of even active redundancy allocation more complex.