Insulin resistance often associated with metabolic syndrome is common and plays a key role amongst lean Indian patients with non-alcoholic fatty liver disease.
FLASH radiation therapy (RT) is a promising new paradigm in radiation oncology. However, a major question that remains is the robustness and reproducibility of the FLASH effect when different irradiators are used on animals or patients with different genetic backgrounds, diets, and microbiomes, all of which can influence the effects of radiation on normal tissues. To address questions of rigor and reproducibility across different centers, we analyzed independent data sets from The University of Texas MD Anderson Cancer Center and from Lausanne University (CHUV). Both centers investigated acute effects after total abdominal irradiation to C57BL/6 animals delivered by the FLASH Mobetron system. The two centers used similar beam parameters but otherwise conducted the studies independently. The FLASH-enabled animal survival and intestinal crypt regeneration after irradiation were comparable between the two centers. These findings, together with previously published data using a converted linear accelerator, show that a robust and reproducible FLASH effect can be induced as long as the same set of irradiation parameters are used.
Adenomyoma is a rare benign lesion occurring commonly in the fundus of the gallbladder in the biliary tract. Ampullary adenomyoma is rarer still, presenting as obstructive jaundice due to its location at the ampulla and may mimic malignancy on clinical and radiological examination. Endoscopic biopsy may not be always diagnostic if the lesion is deep seated. Histologically these lesions show a combination of diverse benign epithelial and mesenchymal elements, which should not be confused with an invasive tumor because of its arrangement. We report three cases of adenomyoma located at the ampulla presenting as obstructive jaundice. The diagnosis was confirmed on pacreaticoduodenectomy resection specimens.
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