Networked embedded objects augmented with smart applications have already started encompassing many aspects of human life. More often these objects are driven by limited power sources and hence estimation of remaining energy in these objects at run time becomes important. Also power profiling provides a rough idea on how long the intended applications will run on the network given the battery-life specification. The proposed component based architecture use a power estimation module for dynamic power profiling. The code for power estimation could be disseminated either through direct burning or over-the-air programming in each objects of the network. The scheme has been implemented and tested on a wireless sensor network set-up where smart objects considered are TelosB nodes running on Contiki operating system. The experiment conducted, the results and observations are presented.
Indian service sector has witnessed the growth of technology at unprecedented pace that has impacted the creation and development of remote working environment. This changing organizational environment and market demands require an alignment between technology and leadership. In this context the current study aims to find the impact of technology on different leadership styles to support distanced working, particularly, after the spread of the global pandemic. For this, 328 respondents working in service sector of Delhi &NCR were surveyedthrough structured questionnaire. Findings of the study revealed that technology has an influence on different leadership styles in supporting distanced working by providing clear communication, skill management, participation, or guiding work behavior. Additionally, technology plays significant role of enabling distanced working through contribution of technology in supporting communication and mobility, determination of technology task-fit, or creating of sense of unity. Thus, using the practices like cloud based internal communication portal or the reward and recognition facility, the benefit of technology could be derivedandbusiness continuity.
Background: It is required to study the bioavailability and biodistribution of specific cholecalciferol formulation before prescribing. Pharmacoscintigraphy is an established radiological-imaging technique that is used to map various drug formulations as they traverses the human body (biodistribution) in real-time. We evaluated the bioavailability and biodistribution pattern, transit time, and gastrointestinal clearance of a single dose of Calcirol® soft gelatin capsule 60,000 IU [an oral cholecalciferol (vitamin D) formulation] using pharmacoscintigraphy.
Methods: Six male healthy adult volunteers were administered a single oral dose of Calcirol® soft gelatin capsule labelled with technetium-99m. Post-dosing, serial venous blood samples were collected till day 27 for the estimation of the plasma levels of 25-hydroxycholecalciferol and 1,25-dihydroxycholecalciferol levels. Different pharmacokinetic parameters were calculated. Sequential static gamma imaging was performed to evaluate the biodistribution of Calcirol® soft gelatin capsule. Descriptive statistics was used. Various pharmacokinetic parameters were calculated from the concentration-time curves. Statistical analysis was carried out using Student’s t-test. Suitable multivariate analysis was performed based on the distribution of data. All statistical analyses were performed using SAS® Software (v 9.4).
Results: The overall absorption of Calcirol® soft gelatin capsule was 93.23%, which was fully from the small intestine. It led to achieving a sufficient level of 25-hydroxycholecalciferol (>60 ng/ml) within 6 hours of oral intake. The levels of plasma 25-hydroxycholecalciferol and 1,25-dihydroxycholecalciferol increased (maximum around 6 and 18 days, respectively). The small intestinal residence time was around 16 hours. No adverse event was noted.
Conclusions: This was the first pharmacoscintigraphy study in the world which demonstrated the favourable bio-distribution of the Calcirol softgels supporting its role in vitamin D supplementation.
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