Helicobacter pylori, a unique gastric pathogen causing chronic inflammation in the gastric mucosa with a possibility to develop gastric cancer has one-third of its proteins still uncharacterized. In this study, a hypothetical protein (HP) namely HPAG1_0576 from H. pylori HPAG1 was chosen for detailed computational analysis of its structural, functional and epitopic properties. The primary, secondary and 3D structure/model of the selected HP was constructed. Then refinement and structure validation were done, which indicated a good quality of the newly constructed model. ProFunc and STRING suggested that HPAG1_0576 shares 98% identity with a carcinogenic factor, TNF-α inducing protein (Tip-α ) of H. pylori. IEDB immunoinformatics tool predicted VLMLQACTCPNTSQRNS from position 19-35 as most potential B-cell linear epitope and SFLKSKQL from position 5-12 as most potent conformational epitope. Alternatively, FALVRARGF and FLCGLGVLM were predicted as most immunogenic CD8+ and CD4+ T-cell epitopes respectively. At the same time findings of IFN epitope tool suggests that, HPAG1_0576 had a great potential to evoke interferon-gamma (IFN-γ) mediated immune response. However, this experiment is a primary approach for in silico vaccine designing from a HP, findings of this study will provide significant insights in further investigations and will assist in identifying new drug targets/vaccine candidates.
Objectives: This research attempts to figure out a comparative pattern of the social response from the peoples of Bangladesh as well as different communities and regarding actions taken by the government during the COVID-19 pandemic in Bangladesh. Else, this study also investigates the shortcomings of the different wing authorities of the Bangladesh Government to reach people of every corner of this country. Methods: In this research, different facts are analyzed from a statistical point of view. Authentic sources like reputed national and international newspapers, governmental release documents, release notes of WHO, etc. were considered for data collection to realize this country’s preparations against the COVID-19 pandemic. Results: From the statistical analysis, this study found that different government authorities partially failed to communicate the measures of the government to the wider public audience. This study has shown that having more tests could have prevented the spread of the virus in Bangladesh. The strong lockdown measures taken by the government were not enough as the population of this country is huge and it is really difficult to maintain social distance in a densely populated country like Bangladesh. Conclusions: The socio-economic condition and decision-makers’ shortcomings could have been overcome if the right plan and action had been taken at the right time. Until the vaccine is available it is recommended that people should keep social distance while going outside, using masks and protection should be mandatory. Furthermore, more health care professionals should be hired and trained to fight this virus. Doi: 10.28991/SciMedJ-2021-03-SI-4 Full Text: PDF
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