Epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare benign vascular lesion presenting as multiple nodules on the head and neck. Surgery had been considered to be the best treatment modality for ALHE. We report the case of a 6-month-old boy with ALHE on his tongue that was treated successfully with oral prednisolone.
A BSTRACT Background: Granular cell tumor (GCT) or Abrikossoff’s tumor is an uncommon neuro-derived tumor in which Schwann cells are found and express S-100 protein. Often, it is a benign lesion. Histopathologically, there are granular cell infiltrations through the entire dermis without necrosis which are periodic acid Schiff (PAS) stain positive and reactive with S-100. The aim of this study is the clinicopathological evaluation of GCT. Material and Methods: In this paper, we described the experience of 6 patients with a GCT in different locations (4 cases in the skin and 2 cases in the mucosa), for example, a case with a tumor in the abdomen and a keloidal-like presentation with a highly sclerotic pattern (an uncommon pathological feature). Another case developed a lesion secondary to physical trauma. Result: In one case, the presence of a lesion in the lower lip associated with actinic damage secondary to chronic sun exposure resulted in misdiagnosis with actinic cheilitis and squamous cell carcinoma. Conclusion: Histopathologically, there were granular cell infiltrations through the entire dermis without necrosis which are PAS-positive and reactive with S-100.
A BSTRACT Background and Objective: Many biological activities and pharmacological usages have been revealed for the Cuscuta species. The present study aimed to assess the beneficial effects of Cuscuta on removing skin dark spots in healthy individuals, which is an important cosmetic concern, especially in women. Materials and Methods: This prospective, interventional before–after trial was conducted in 70 healthy individuals without any evidence of skin or systemic disorders who presented for consultation on removing skin darkening. The Cuscuta extract was prepared and then assessed for plant quality control and lack of microbial contamination. The content of melanin at baseline and at 1 and 3 months after intervention was assessed using Dermacatch, an accurate skin colorimetric measurement tool. Results: Comparison of the melanin content of the lesions and treated area to the surrounding normal area at baseline and at 1 month after treatment showed a significant reduction in melanin content from 519.61 ± 45.09 to 498.50 ± 39.35 ( P < 0.001). This reducing trend remained significant from the first month to the third month after treatment (from 498.50 ± 39.35 to 483.53 ± 40.99, P < 0.001). This decreasing trend was persistent even after adjusting baseline characteristics including gender, age, and duration of skin lesions. Both patients and investigators had high satisfaction level with the anti-melanogenesis effect of Cuscuta extract. Conclusion: Cuscuta extract is useful for removing hyperpigmented lesions and for skin lightening in healthy individuals.
Coagulase-negative Staphylococci (CoNS) are one of the most frequently isolated bacteria in the clinical microbiology laboratory. These bacteria are normal inhabitants of human skin and mucous membranes; also, they have emerged as significant nosocomial pathogens. Staphylococcus saprophyticus is a Gram-positive bacterium well known for causing uncomplicated urinary tract infections in young sexually active females, responsible for complications including urinary tract infections, epididymitis, prostatitis, and acute pyelonephritis. CoNS can be divided into two groups based on susceptibility to novobiocin. The novobiocin-susceptible species include S. epidermidis, S. haemolyticus, S. hominins, S. lugdunensis, S. schleiferi, and the novobiocin-resistance species, including S. saprophyticus and S. xylosus. The acute uncomplicated UTI, including cystitis and pyelonephritis, is frequent in an immunocompetent nonpregnant female population, the second most common cause of community-acquired urinary tract bacterial infection in women after the Escherichia coli. S. saprophyticus is a part of the normal human flora which colonizes the rectum, urethra, cervix, and gastrointestinal tract. Bacterial colonization of the bladder and ureter epithelium occurs via several types of adhesin, including hemagglutinins with autolytic properties. Also, some strains can create and produce biofilms to increase their pathogenicity.
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