Background and objective: Male breast cancer is a rare condition and its underlying mechanism is not well understood. Therefore, we conducted this study to find out the clinicopathological characteristics of a series of male breast cancer consecutively treated in Yazd, Iran, over a 15-year period. Material and method: We retrospectively analyzed clinicopathological characteristics using a cohort of 39 male breast cancer patients who were surgically treated at the Shahid Sadoughi Hospital, Yazd, Iran, between 2001 and 2016. The demographic data, age, histology, disease stage, hormone receptor (HR) status, overall survival status, surgery treatment procedures, adjuvant treatment, and tumor stage were registered. A total of 39 male breast cancer patients were included. Results: The median age at diagnosis was 57.92 years (range, 21-95 years). Eight patients (20.5%) had family history of breast cancer. The collective 2-, 5-, and 10-year survival in our cohort was 83.4%, 43.2%, and 10.3%, respectively. The disease stage was significantly associated with overall survival (p=0.001). Conclusion: In our cohort, survival rates as well as the median age at diagnosis were lower than those reported in previous reports. Moreover, the disease stage was a main independent prognostic factor for survival.
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