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<p><strong><em>Introduction:</em></strong><em> </em><em>HIV-Associated Nephropathy </em><em>may shorten the life expectancy of affected patients. Its </em><em>early detection is beneficial for the indication of treatment and hence prevention of progression to the end-stage of renal failure. The final diagnosis requires renal biopsy which may be difficult in some African area; clinical and ultrasound criteria may be helpful. The aim of this study was twofold: to characterize renal sonographic changes in HIV-positive patients with HIV associated Nephropathy and to investigate the correlation between renal sonographic changes and histological lesions in central Africa.</em></p><p><strong><em>Methods:</em></strong><em> A prospective and multi-center study conducted from January 2013 to July 2015 included, for renal ultrasound evaluation of the length, thickness and echogenicity, forty two of the 334 biologically confirmed HIV-positive patients who presented with significant proteinuria suggestive of HIV associated Nephropathy. And transcutaneous renal biopsy with histopathology has been performed in 16 patients of them. </em><em>Statistical analyzes were used.</em></p><p><strong><em>Results:</em></strong><em> There were 100 men and 234 women; proteinuria was positive in 42 patients, (12.6%). The average length of the kidneys was 111 ± 8 mm (normal), with 10% of patients with pathological values (5% with kidneys of reduced size and 5%, increased size). The kidneys had an average thickness of 44 ± 5 mm (normal), with 21% of patients presenting an increase in renal thickness. Quantitative echogenicity was calculated at 1.492 ± 0.793 (normal), with 79% of patients with increased quantitative echogenicity. Of the 16 patient</em><em>s</em><em> biopsied, all had tubulo-interstitial lesion</em><em>s</em><em>, and 75% of them associated with glomerular le</em><em>s</em><em>ion</em><em>s</em><em>.</em><em> </em><em>In simple correlation analysis, tubular dilatation was positively and significantly related to quantitative echogenicity (r = 0.67, p &lt; 0.01) and to renal parenchyma thickness (r = 0.67; 0.85, p ? 0.05). The relationship between the other parameters studied did not reach statistical significance. In multiple linear regression, glomerular hyalinosis, glomerular proliferation, tubular dilatation, tubular atrophy, interstitial fibrosis, and interstitial inflammation emerged as the main determinants of quantitative echogenicity; however, the relationship was statistically significant only for tubular dilatation (? = 0.305, p = 0.034).</em><em></em></p><strong><em>Conclusion:</em></strong><em> The present study showed the characteristic of renal change and the relation with histology found in central Africans patients.</em>