In this study, the trypomastigotes of a Y strain of Trypanosoma cruzi were inoculated intraperitoneally into male BALB/c mice weighing approximately 25 g each, which were divided into groups for evaluation of the trypanocidal activity. For the treatment of experimental groups, encapsulated and unencapsulated (−)‐cubebin, Benznidazole, and two groups as negative controls were used. The encapsulated (−)‐cubebin showed a 68.1 % encapsulation efficiency. The parasitemia peak of substances remained around the 9th day after the observed reduction in the number of circulating trypomastigotes. The encapsulated (−)‐cubebin and (−)‐cubebin unloaded showed a decrease of 61.3 % and 58.5 % in the number of parasites as compared to the negative control, respectively. Moreover, animals treated with encapsulated (−)‐cubebin had a higher survival time as compared to the other groups. In conclusion, the results obtained were more promising for encapsulated (−)‐cubebin as compared to unloaded particles.
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