The solubility of isatin in different solvents was studied by a gravimetrical method from (298.15 to 318.15) K under atmospheric pressure and the solubility data were correlated against temperature. The solvents selected for the present study are: water, methanol, ethanol, 1-butanol, dichloromethane, dichloroethane, chloroform and carbon tetra chloride. Among chlorinated solvents, solubility is observed to be maximum in 1, 2-dichloroethane and minimum in dichloromethane whereas in alcohols, maximum solubility is observed in methanol. In water, solubility is found to be minimum. Further, some thermodynamic parameters such as Gibb's energy (ΔG sol ), heat of solution (ΔH sol ) and entropy of solution (ΔS sol ) have also been evaluated.

The solubility of enrofloxacin sodium in methanol, acetone, 1,2-dichloromethane, and 1,2-dichloroethane was measured by a gravimetrical method from (293.15 to 310.15) K under atmospheric pressure, and the solubility data were correlated against temperature.

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The solubility of ofloxacin in 1,2-dichloromethane, chloroform, carbon tetrachloride, and water was measured by a gravimetrical method from (293.15 to 313.15) K under atmospheric pressure, and the solubility data were correlated against temperature. The solubility is at a minimum in water and a maximum in chloroform. Further, some thermodynamic parameters such as enthalpy, Gibbs energy, and entropy for dissolution have also been evaluated. For 1,2-dichloromethane and chloroform, enthalpy, Gibbs energy, and entropy values are very close and lower than those for carbon tetrachloride and water.

The solubility of difloxacin in methanol, acetone, and ethanol was measured by a gravimetrical method from (293.15 to 313.15) K under atmospheric pressure, and the solubility data were correlated against temperature.