Furosemide (FRMD) is a loop diuretic, poorly water-soluble (BCSClass II) drug. It is used for the treatment of edema associated with congestive heart failure, cirrhosis of the liver and renal disease, including the nephrotic syndrome. Besides this it is also used for the treatment of hypertension. In order to enhance the extent of absorption, it is necessary to improve its solubility. To increase its solubility and dissolution rate, various solubility enhancement methods like physical mixing, solvent evaporation, kneading and hot melt by using carriers such as Poloxamer 407 and Modified xanthan gum in different ratios were investigated. Drug-carrier interactions were investigated by FTIR spectroscopy and differential scanning calorimetry. The studies showed that solubility and dissolution rate of Furosemide were distinctively increased in the prepared drug carrier mixture compared to that of pure Furosemide. The studies showed that dissolution and solubility parameters progressively improved with increasing the polymer proportion in the drug carrier mixtures. Poloxamer 407 in 1:3 ratio with the drug showed an increase in solubility and dissolution compared to the other polymers.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.