Pantoprazole (1), a substituted benzimidazole derivative, is an
irreversible proton pump inhibitor, essentially used for the
prevention and treatment of gastric acid-related diseases. The
process for its preparation generally suffers from the drawback
of producing a potential sulfone impurity (5). The present work
details a report of the journey towards the development of a
simple, single-pot process for the production of pantoprazole,
substantially free from sulfone impurity (5). The detailed study
of the different parameters affecting the purity and yield of
the compound has been presented.
Improved Process for Paroxetine Hydrochloride Substantially Free from Potential Impurities. -Selected steps in the synthesis of the antidepressant drug paroxetine (IV) are optimized to control potential impurities and to meet ICH standards. -(GANGULA, S.; KOLLA, N. K.; ELATI, C.; DONGAMANTI, A.; BANDICHHOR*, R.; Synth. Commun. 42 (2012) 22, 3344-3360, http://dx.
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