efficacy and common tolerability challenges, provided that the studies used for these calculations are similar enough. Number needed to harm (NNH) values may be even more helpful when distinguishing among treatments that are relatively otherwise similar.2 The NNH can be for overall tolerability (discontinuation because of an adverse effect) or the occurrence of specific adverse effects of concern for individual patients being treated (such as sedation, weight gain or akathisia). Moreover, ratios of NNH to NNT can provide overall estimates of the risk-benefit trade-offs involved. Finally, we suggest that all of the above concepts are straightforward enough for average clinicians to calculate and understand. 4 Citrome L, Ketter TA. Teaching the philosophy and tools of evidence-based medicine: misunderstandings and solutions.
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