Molecular communication (MC) is the most promising communication paradigm for nanonetwork realization since it is a natural phenomenon observed among living entities with nanoscale components. Since MC significantly differs from classical communication systems, it mandates reinvestigation of information and communication theoretical fundamentals.The closest examples of MC architectures are present inside our own body. Therefore, in this paper, we investigate the existing literature on intra-body nanonetworks and different MC paradigms to establish and introduce the fundamentals of molecular information and communication science. We highlight future research directions and open issues that need to be addressed for revealing the fundamental limits of this science. Although the scope of this development encompasses wide range of applications, we particularly emphasize its significance for life sciences by introducing potential diagnosis and treatment techniques for diseases caused by dysfunction of intra-body nanonetworks.

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While mm-wave systems are a mainstay for 5G communications, the inexorable increase of data rate requirements and user densities will soon require the exploration of next-generation technologies. Among these, Terahertz (THz) band communication seems to be a promising direction due to availability of large bandwidth in the electromagnetic spectrum in this frequency range, and the ability to exploit its directional nature by directive antennas with small form factors. The first step in the analysis of any communication system is the analysis of the propagation channel, since it determines the fundamental limitations it faces. While THz channels have been explored for indoor, short-distance communications, the channels for wireless access links in outdoor environments are largely unexplored. In this paper, we present the -to our knowledge -first set of doubledirectional outdoor propagation channel measurements for the THz band. Specifically, the measurements are done in the 141 -148.5 GHz range, which is one of the frequency bands recently allocated for THz research by the Federal Communication Commission (FCC). We employ double directional channel sounding using a frequency domain sounding setup based on RF-over-Fiber (RFoF) extensions for measurements over 100 m distance in urban scenarios. An important result is the surprisingly large number of directions (i.e., direction-of-arrival and direction-ofdeparture pairs) that carry significant energy. More generally, our results suggest fundamental parameters that can be used in future THz Band analysis and implementations.

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The THz band (0.1-10 THz) has attracted considerable attention for next-generation wireless communications, due to the large amount of available bandwidth that may be key to meet the rapidly increasing data rate requirements. Before deploying a system in this band, a detailed wireless channel analysis is required as the basis for proper design and testing of system implementations. One of the most important deployment scenarios of this band is the outdoor microcellular environment, where the Transmitter (Tx) and the Receiver (Rx) have a significant height difference (typically ≥ 10 m). In this paper, we present double-directional (i.e., directionally resolved at both link ends) channel measurements in such a microcellular scenario encompassing street canyons and an open square. Measurements are done for a 1 GHz bandwidth between 145-146 GHz and an antenna beamwidth of 13 degree; distances between Tx and Rx are up to 85 m and the Tx is at a height of 11.5 m from the ground. The measurements are analyzed to estimate path loss, shadowing, delay spread, angular spread, and multipath component