Cervical intra-epithelial neoplasia is associated with Human Papilloma Virus (HPV) infection and promoted by Herpes Simplex Virus -2, Chlamydia and other microbes. Fast biochemical test for preliminary diagnosis of cervical HPV infection is not available yet. We studied 29 women with condyloma and cervical intraepithelial neoplasia I, I1 before and after laser treatment and 36 healthy women. HPV-16 and 18 were identified by PCR. The structures of HPV were found electron microscopically in some infected cell of bioptates of endometrium. Gamma-glutamyl transpeptidase (GGTP), alanine and aspartate aminotransferases (ALT, AST), lactate and alpha-hydroxybutyrate dehydrogenases (LDH, AHBDH), creatine kinase (CK), alkaline phosphatases, choline esterase and level of Fe, Ca, P(inorg) were investigated spectrophotometrically. In vaginal discharge of a majority of HPV infected women the activity of GGTP, ALT, AST, LDH, AHBDH, CK and level of Fe were higher than that of healthy women. Increased activity of aminoacid metabolism during HPV infection proved that HPV perhaps aided the synthesis of viral capsid proteins. The laser treatment decreased the elevation of the enzymatic values. Activity of some enzymes and level of Fe may precede the appearance of the clinical signs or witness the presence of cervical HPV infection. sequence in Tunisian grapevine cultures papillomavirus infection of the lower genital tract 677 Human papilloma virus (HPV) types detected among Macedonian patients with cervical abnormalities
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